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BioLineRx begins phase 2 trial for pancreatic cancer treatment By Investing.com

February 28, 2024
in Markets
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BioLineRx begins phase 2 trial for pancreatic cancer treatment By Investing.com

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BioLineRx begins phase 2 trial for pancreatic cancer treatment
© Reuters.

TEL AVIV – BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a biopharmaceutical firm, has initiated the Part 2 CheMo4METPANC medical trial, dosing the primary affected person in a examine to evaluate the effectiveness of its drug candidate motixafortide together with different most cancers therapies for treating pancreatic most cancers.

The trial, carried out in collaboration with Columbia College, is evaluating motixafortide alongside a PD-1 inhibitor, cemiplimab, and normal chemotherapies gemcitabine and nab-paclitaxel, in comparison with the chemotherapy medication alone. The examine marks the primary giant, multi-center, randomized analysis of this mixture for first-line pancreatic ductal adenocarcinoma (PDAC) remedy.

Philip Serlin, CEO of BioLineRx, expressed optimism based mostly on preliminary knowledge, highlighting the pressing want for brand spanking new remedies given the restricted success of conventional immunotherapies in addressing PDAC, which frequently results in poor affected person outcomes.

The CheMo4METPANC trial goals to enroll 108 sufferers, specializing in progression-free survival as the first endpoint. Secondary targets embrace security, response fee, illness management fee, period of medical profit, and total survival.

Motixafortide, already authorised by the FDA for stem cell mobilization in a number of myeloma sufferers, can be being examined as a monotherapy and together with different medication for various indications.

Pancreatic most cancers is understood for its low early analysis fee and dismal prognosis. In the US alone, an estimated 66,000 adults can be recognized with the illness in 2024. The 5-year relative survival fee is exceptionally low, significantly for sufferers with metastatic most cancers.

The drug’s mechanism, inhibiting the CXCR4 receptor, is designed to reinforce the immune system’s response to the tumor. The pilot section of the trial confirmed promising outcomes, with a excessive illness management fee amongst contributors.

BioLineRx, headquartered in Israel with operations within the U.S., is concentrated on creating therapies for oncology and uncommon ailments. The corporate’s pipeline consists of remedies for sickle cell illness and strong tumors.

This information relies on a press launch assertion.

This text was generated with the help of AI and reviewed by an editor. For extra data see our T&C.

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Tags: BeginsBioLineRxcancerInvesting.compancreaticPhasetreatmenttrial
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